Impact of growth hormone with hypocaloric nutrition on nitrogen balance and blood glucose in patients after gastrointestinal operation

• Published in: Zhonghua wei chang wai ke za zhi Vol. 11; no. 1; p. 50
• Main Authors: Zhang, Ming-ming, Zheng, Ya-min, He, Tao, Zhou, Yong, Qian, Kun, Wu, Xiao-ting
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2008
• Subjects: Adult; Aged; Blood Glucose - metabolism; Caloric Restriction; Digestive System Surgical Procedures; Female; Human Growth Hormone - therapeutic use; Humans; Male; Middle Aged; Nitrogen - metabolism; Nutritional Support - methods; Postoperative Period; Recombinant Proteins - therapeutic use
• ISSN: 1671-0274

To evaluate the impact of recombinant human growth hormone (rhGH) combined with hypocaloric nutrition on nitrogen balance and blood glucose in patients after gastrointestinal operation. Forty-eight patients undergone abdominal operations were randomly divided into either subcutaneous rhGH (0.15 IU/kg) or placebo (menstruum) injection daily for 7 days postoperatively. These two groups had similar nutritional intakes. Body weight, blood cell count, liver and renal function, plasma albumin, prealbumin, transferrin and fibronectin were measured at day 1 before operation as baseline and day 3 and day 10 after operation by standard laboratory techniques. Nitrogen balance and blood glucose were measured from day 3 to day 9 after operation. At postoperative day 10, the cumulative nitrogen balance and the level of plasma fibronectin were significantly higher in rhGH group [13.21 g,(104.77+/-19.94) mg/L] than those in placebo group [-6.88 g, (93.03+/-16.03) mg/L] (P<0.05). Furthermore, at day 4 and from day 6 to day 9