Clinical application of proton magnetic resonance spectroscopy in children with idiopathic epilepsy

This study examined the biochemical metabolism by proton magnetic resonance spectroscopy ('H-MRS) in order to explore the value of 'H-MRS in idiopathic epilepsy in children. Thirty-three children with idiopathic epilepsy (14 cases with history of febrile seizures and 19 cases without) and...

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Bibliographic Details
Published inZhongguo dang dai er ke za zhi Vol. 12; no. 6; p. 425
Main Authors Shao, Xiao-Li, Zhou, Zhong-Shu, Hong, Wen
Format Journal Article
LanguageChinese
Published China 01.06.2010
Subjects
Aspartic Acid - analogs & derivatives
Aspartic Acid - analysis
Child
Child, Preschool
Choline - analysis
Epilepsy - diagnosis
Epilepsy - metabolism
Female
Humans
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy - methods
Male
Phosphocreatine - analysis
Protons
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Summary:This study examined the biochemical metabolism by proton magnetic resonance spectroscopy ('H-MRS) in order to explore the value of 'H-MRS in idiopathic epilepsy in children. Thirty-three children with idiopathic epilepsy (14 cases with history of febrile seizures and 19 cases without) and six normal controls experienced MRI of the skull and brain and single-voxel 'H-MRS examinations of the hippocampi-temporal lobe. The signal intensities of N-acetylaspartate (NAA), eatine+phosphocreatine (Cr), choline-containing compounds (Cho) and lactate (Lac) and the ratios of NAA/ (Cho+Cr) and Lac/Cr were compared between the patients and normal controls. MRI examination showed that only one child with epilepsy had myelin dysplasia. 'H-MRS examination showed that the ratio of NAA/ (Cho+Cr) in the epilepsy group was lower than that in the control group (0.64+/-0.07 vs 0.73+/-0.05; P<0.01). The epileptic children with history of febrile seizures had a more decreased ratio of NAA/ (Cho+Cr) compared with those without the his
ISSN:1008-8830