Therapeutic effect of Tripterygium wilfordii multiglycosides on proteinuria in kidney transplant recipients

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 28; no. 12; p. 2269
• Main Authors: Huang, Yun, Long, Tian-biao, Zhan, Feng, Pan, Chu-ying, Chen, Dao-jun, Lin, Shu-dian
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2008
• Subjects: Adult; Aged; Female; Glycosides - therapeutic use; Graft Survival - immunology; Humans; Kidney Transplantation - adverse effects; Kidney Transplantation - immunology; Male; Middle Aged; Proteinuria - drug therapy; Proteinuria - etiology; Tripterygium - chemistry; Young Adult
• ISSN: 1673-4254

To study the effect of multiglycosides of Tripterygium wilfordii (MTW) for treatment of proteinuria in kidney transplant recipients. Forty-five kidney transplant recipients with proternuria were randomized into 3 groups (n=15) and received full daily dose (1 mg/kg) MTW, half dose (0.5 mg/kg) MTW or no MTW (control) in addition to immunosuppressant therapy. The 24-hour urinary protein (24 h Upro), blood urea nitrogen (BUN), serum creatinine (Scr), dose of ciclosporin and the adverse effects of MTW were recorded. MTW at both the full dose and half dose significantly reduced the 24 h Upro as compared to exclusive immunosuppressant therapy (P<0.05). The therapeutic dose of ciclosporin in patients with full and half dose of MTW was significantly lower than that in the control group (P<0.05), and the patients receiving full dose MTW showed greater adverse effects than those having half dose MTW (P<0.05). MTW can significantly ameliorate proteinuria, reduce the therapeutic dose of ciclosporin and protect the renal f