The study of hypertonic saline and hydroxyethyl starch treating severe sepsis

To evaluate the effect of 7.5% hypertonic saline (HS) and 6% hydroxyethyl starch (HES) 130/0.4 on early fluid resuscitation for severe sepsis. Prospective randomized control trial was carried out in intensive care unit (ICU) of the Affiliated Hospital of Jianghan University. One hundred and thirty f...

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Published inZhongguo wei zhong bing ji jiu yi xue Vol. 23; no. 3; p. 150
Main Authors Zhu, Guo-chao, Quan, Zhuo-yong, Shao, Yong-sheng, Zhao, Jian-guo, Zhang, Ying-tian
Format Journal Article
LanguageChinese
Published China 01.03.2011
Subjects
Aged
Female
Humans
Hydroxyethyl Starch Derivatives - therapeutic use
Male
Middle Aged
Prospective Studies
Saline Solution, Hypertonic - therapeutic use
Sepsis - therapy
Shock, Hemorrhagic
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Summary:To evaluate the effect of 7.5% hypertonic saline (HS) and 6% hydroxyethyl starch (HES) 130/0.4 on early fluid resuscitation for severe sepsis. Prospective randomized control trial was carried out in intensive care unit (ICU) of the Affiliated Hospital of Jianghan University. One hundred and thirty five patients with severe sepsis were randomly divided into three groups, each group consisted of 45 patients. Patients in HS+HES group received lactated Ringer solution following 4 ml/kg of 7.5% HS and 6% HES 130/0.4 500 ml, those in HES group received lactated Ringer solution following 6% HES 130/0.4 500 ml, and those in the lactated Ringer group (RL group) received lactated Ringer solution only.Mean arterial pressure (MAP), oxygenation index (PaO₂/FiO₂),arterial lactate (Lac),lactate clearance rate, acute physiology and chronic health evaluation II(APACHEII) score,fluid infusion volume, urine output as well as incidence of multiple organ dysfunction syndrome (MODS), and mortality were compared among three groups
ISSN:1003-0603
DOI:10.3760/cma.j.issn.1003-0603.2011.03.008