Effects of different oxygen flow rates on myocardial ischemia-reperfusion injury in rabbits

To explore the effects of different oxygen flow rates during cardiopulmonary bypass (CPB) on myocardial ischemia-reperfusion (IR) injury in rabbits. Thirty rabbits were randomized equally into groups A, B and C to receive controlled oxygen reperfusion at low, normal and high flow rates (25, 50, and...

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Published inNan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 29; no. 7; p. 1477
Main Authors Gong, Wei, Liu, Jian-Xin, Jin, Long-Yu, Wang, Dian-Jun, Hong, Chao, Jiang, Zhi-Bin
Format Journal Article
LanguageChinese
Published China 01.07.2009
Subjects
Animals
Cardiopulmonary Bypass
Myocardial Reperfusion Injury - prevention & control
Oxygen - administration & dosage
Rabbits
Reperfusion - methods
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Summary:To explore the effects of different oxygen flow rates during cardiopulmonary bypass (CPB) on myocardial ischemia-reperfusion (IR) injury in rabbits. Thirty rabbits were randomized equally into groups A, B and C to receive controlled oxygen reperfusion at low, normal and high flow rates (25, 50, and 80 ml.kg(-1).min(-1), respectively). Serum concentration of CK-MB and cTnT were tested by ELISA before the operation (T0) and after 30 min (T1), 2 h (T2), 12 h (T3) and 24 h (T4) of reperfusion. W/D, SOD and MDA of the myocardium were determined before and at 60 min after reperfusion. The ultrastructural alterations of the myocardium were observed. Serum concentration of CK-MB and cTnT in the 3 groups increased significantly after the operation, and their levels were the lowest in group A (P<0.05). W/D and MDA in the myocardium was also the lowest, while SOD the highest in group A (P<0.05). Ultrastructural pathologies were found in all the 3 groups, but relatively mild in group A. Low oxygen flow rate during contro
ISSN:1673-4254