Expression of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia

The objective of this study was to investigate the expressions of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia (CAA) and their significance. The mRNA expressions of EPO, SCF and GM-CSF from 35 CAA patients and 10 healthy individuals were d...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 16; no. 5; p. 1100
Main Authors Wang, Yan, Xu, Rui-Rong
Format Journal Article
LanguageChinese
Published China 01.10.2008
Subjects
Adolescent
Adult
Aged
Anemia, Aplastic - genetics
Anemia, Aplastic - metabolism
Anemia, Aplastic - pathology
Bone Marrow - metabolism
Bone Marrow - pathology
Child
Chronic Disease
Erythropoietin - metabolism
Female
Granulocyte-Macrophage Colony-Stimulating Factor - metabolism
Humans
Male
Middle Aged
RNA, Messenger - genetics
Stem Cell Factor - metabolism
Young Adult
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Summary:The objective of this study was to investigate the expressions of hematopoietic cytokines EPO, SCF and GM-CSF in bone marrow cells of patients with chronic aplastic anemia (CAA) and their significance. The mRNA expressions of EPO, SCF and GM-CSF from 35 CAA patients and 10 healthy individuals were detected by semi-quantitative RT-PCR. The results showed that the levels of EPO, SCF and GM-CSF in CAA patients were obviously lower than those in the healthy individuals (p < 0.01). It is concluded that the immunity disorder mediated by hematopoietic cytokines is one of the pathogenesis in the CAA patients, it provided theoretical basis for guiding clinical treatment.
ISSN:1009-2137