Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries

Under study were features of allele polymorphism of genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A 2756G), methionine synthase reductase (MTRR A66G) and methylenetetrahydrofolate dehydrogenase (MTHFD G1958A) in patients with atherosclerosis of the lo...

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Published inVestnik hirurgii im. I.I. Grekova Vol. 168; no. 6; p. 41
Main Authors Klenkova, N A, Kapustin, S I, Saltykova, N B, Shmeleva, V M, Blinov, M N
Format Journal Article
LanguageRussian
Published Russia (Federation) 2009
Subjects
Alleles
Atherosclerosis - blood
Atherosclerosis - diagnosis
Atherosclerosis - genetics
DNA - genetics
Female
Ferredoxin-NADP Reductase - genetics
Flavoproteins
Folic Acid - analogs & derivatives
Folic Acid - blood
Folic Acid - genetics
Follow-Up Studies
Genetic Predisposition to Disease
Genotype
Homocysteine - blood
Homocysteine - genetics
Humans
Leg - blood supply
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Prognosis
Severity of Illness Index
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Summary:Under study were features of allele polymorphism of genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C), methionine synthase (MS A 2756G), methionine synthase reductase (MTRR A66G) and methylenetetrahydrofolate dehydrogenase (MTHFD G1958A) in patients with atherosclerosis of the lower extremity arteries (ALEA). Patients with hyperhomocysteinemia (HHcy) had statistically significant increase of allele MTHFR 677T and MTRR 66GG as compared both with the control group and with the group of patients without HHcy. It suggests that polymorphism of genes involved in homocystein and folate metabolism might affect the risk of HHcy in patients with ALEA.
ISSN:0042-4625