Apoptosis of psoriatic keratinocytes and the severity of patients' condition

To investigate the correlation between the apoptosis of psoriatic keratinocytes (KCs) in the psoriatic lesions and patient's condition. Thirty patients with psoriasis were included. Activated caspase-3 was examined by colorimetric method in skin biopsy specimens. The apoptotic KCs were detected...

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Published inZhong nan da xue xue bao. Journal of Central South University. Yi xue ban Vol. 31; no. 6; p. 936
Main Authors Chen, Jing, Lu, Jian-yun, Tang, Zhao-hui, Zuo, Cheng-xin, Huang, Jin-hua
Format Journal Article
LanguageChinese
Published China 01.12.2006
Subjects
Adolescent
Adult
Aged
Apoptosis
Caspase 3 - metabolism
Child
Female
Humans
Keratinocytes - pathology
Male
Middle Aged
Psoriasis - diagnosis
Psoriasis - pathology
Severity of Illness Index
Young Adult
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Summary:To investigate the correlation between the apoptosis of psoriatic keratinocytes (KCs) in the psoriatic lesions and patient's condition. Thirty patients with psoriasis were included. Activated caspase-3 was examined by colorimetric method in skin biopsy specimens. The apoptotic KCs were detected with terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling (TUNEL) assay in skin biopsy specimens. The severities of 26 patients with psoriasis vulgaris (PV) were assessed using the PASI scoring system and the severities of psoriatic lesions. Apoptotic indexes (AI) were higher in the pustular psoriatic lesions than those in the vulgaris psoriatic lesions (P<0.05). In 26 patients with PV, AI and activated caspase-3 in the lesions were significantly higher in the progressive stage than those in the static and the regressive stages (P<0.05). There were no correlations between PASI and AI or the expression of activated caspase-3 in PV lesions (P>0.05). The severities of psoriatic lesions were positiv
ISSN:1672-7347