The changes of memory and their correlations to S100beta protein as well as neuron-specific enolase in patients with obstructive sleep apnea-hypopnea syndrome

• Published in: Lin chuang er bi yan hou ke za zhi Vol. 25; no. 3; p. 105
• Main Authors: Feng, Huiwei, Fan, Xianliang, Jiang, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2011
• Subjects: Adult; Aged; Case-Control Studies; Humans; Male; Memory; Middle Aged; Nerve Growth Factors - blood; Phosphopyruvate Hydratase - blood; S100 Calcium Binding Protein beta Subunit; S100 Proteins - blood; Sleep Apnea, Obstructive - blood; Sleep Apnea, Obstructive - psychology
• ISSN: 1001-1781

To explore the possible mechanism of brain damage and memory impairment in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) by detecting the memory, serum S100beta protein, neuron specific enolase( NSE) and analyzing the relationship among them. Thirty patients with moderate or severe OSAHS (AHI > 20/h) and twenty normal controls were included in this study. All subjects were detected by polysomnography in the sleep laboratory and the memory of them were evaluated before PSG examination. Memory tests including point memory, association learning, picture free recall, meaningless picture recognition, face characters associated memory have been conducted. The serum S100beta protein was detected by ELISA and the serum NSE was detected by immunoradiometric assay. The relationship between memory and serum S100beta as well as NSE were analyzed in both experiment group and control group. The score of point memory, association learning, meaningless picture recognition, face characters associated memory