A three-year follow-up study on sera specific antibody in severe acute respiratory syndrome cases after the onset of illness

To study the variation of specific antibody among convalescent of severe acute respiratory syndrome (SARS) patients through a three-year program. Sera samples were collected from SARS cases in the 5th, 20th and 35th month after onset of the illness. The SARS-CoV specific antibody was detected for al...

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Bibliographic Details
Published inZhōnghuá liúxíngbìng zázhì Vol. 28; no. 4; p. 343
Main Authors Xie, Shu-yun, Zeng, Guang, Xia, Shi-chang, Zhang, Pan-he, Yin, Wei-dong, Liu, Bi-yao, Yang, Shi-gui, Cao, Wu-chun
Format Journal Article
LanguageChinese
Published China 01.04.2007
Subjects
Antibodies, Neutralizing - analysis
Enzyme-Linked Immunosorbent Assay
Follow-Up Studies
Humans
Severe Acute Respiratory Syndrome - immunology
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Summary:To study the variation of specific antibody among convalescent of severe acute respiratory syndrome (SARS) patients through a three-year program. Sera samples were collected from SARS cases in the 5th, 20th and 35th month after onset of the illness. The SARS-CoV specific antibody was detected for all of them by ELISA and neutralized test simultaneously. The titer of neutralizing antibodies was calculated using Reed-Muench method, and the comparison between different time groups was analyzed regarding the variance of data on repeated measures after logarithm conversion. 13, 17 and 13 sera samples were collected in the 5th, 20th and 35th month after onset. Results showed that despite the fact that the positive rates of ELISA antibody were 100%, 82.4% and 84.6% respectively,the neutralizing antibody was still positive for all the samples. The average neutralizing antibody titers were 1:43 (1:16-1:203), 1:36 (1:17-1:59) and 1:21 (1:10-1:39) on the 5th, 20th and 35th month after onset, and the differences were sta
ISSN:0254-6450