Effect of vascular endothelial growth factor and tumor necrosis factor receptor for treatment of avascular necrosis of the femoral head in rabbits

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 28; no. 12; p. 2177
• Main Authors: Hu, Zhi-ming, Zhou, Ming-qian, Gao, Ji-min
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2008
• Subjects: Animals; Drug Therapy, Combination; Female; Femur Head Necrosis - chemically induced; Femur Head Necrosis - drug therapy; Male; Rabbits; Random Allocation; Receptors, Tumor Necrosis Factor - therapeutic use; Tumor Necrosis Factor-alpha - blood; Vascular Endothelial Growth Factor A - therapeutic use
• ISSN: 1673-4254

To evaluate the therapeutic effect of vascular endothelial growth factor (VEGF) and tumor necrosis factor receptor (TNFR) on avascular necrosis of the femoral head in rabbits. Avascular necrosis of the femoral head was induced in 26 New Zealand white rabbits by injections of horse serum and prednisolone. The rabbits were then divided into VEGF/TNFR treatment group, VEGF treatment group, and untreated model group, with another 4 normal rabbits as the normal control group. In the two treatment groups, the therapeutic agents were injected percutaneously into the femoral head. Enzyme-linked immunosorbent assay was performed to determine the concentration of TNF-alpha in rabbit serum followed by pathological examination of the changes in the bone tissues, bone marrow hematopoietic tissue and the blood vessels in the femoral head. Compared with the model group, the rabbits with both VEGF and TNFR treatment showed decreased serum concentration of TNF-alpha with obvious new vessel formation, decreased empty bone lacu