Studies on the anti-tumor activity principles of a marine-derived fungus BZYT-21

• Published in: Zhong yao cai Vol. 31; no. 9; p. 1343
• Main Authors: Gao, Zong-Hua, Ma, Li-Ying, Shen, Yun-Xiu
• Format: Journal Article
• Language: Chinese
• Published: China 01.09.2008
• Subjects: Alkaloids - chemistry; Alkaloids - isolation & purification; Amides - chemistry; Amides - isolation & purification; Antineoplastic Agents - chemistry; Antineoplastic Agents - isolation & purification; Ergosterol - analogs & derivatives; Ergosterol - chemistry; Ergosterol - isolation & purification; Fungi - chemistry; Magnetic Resonance Spectroscopy; Marine Biology; Molecular Structure; Mycelium - chemistry; Phytosterols - chemistry; Phytosterols - isolation & purification
• ISSN: 1001-4454

To study the chemical constituents of a marine-derived fungus possessing anti-tumor activity. The compounds were isolated by various chromatographic methods and their structures were elucidated through spectroscopic analysis and chemical and physical properties. Nine compounds were isolated and identified as: (S)-(-)-N-benzoylphenylalaninol, asperphnamate, cerevisterol, (22E, 24R)-6beta-methnoxyergosta-7,22-diene-3beta, 5alpha-diol, (22E, 24R)-5alpha, 6alpha-epoxy-ergosta-8, 22-diene-3beta, 7alpha-diol, (22E, 24R) -3beta, 5alpha, 9alpha-trihydroxyergosta-7, 22-diene-6-one, (22E, 24R) -3beta-hydroxy-ergosta-5, 8, 22-trien-7-one, ergosterol, ergosterol peroxide. (22E, 24R)-3beta-hydroxy-ergosta-5, 8, 22-trien-7-one is isolated from microorganisms for the first time.