Studies on the anti-tumor activity principles of a marine-derived fungus BZYT-21

To study the chemical constituents of a marine-derived fungus possessing anti-tumor activity. The compounds were isolated by various chromatographic methods and their structures were elucidated through spectroscopic analysis and chemical and physical properties. Nine compounds were isolated and iden...

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Bibliographic Details
Published inZhong yao cai Vol. 31; no. 9; p. 1343
Main Authors Gao, Zong-Hua, Ma, Li-Ying, Shen, Yun-Xiu
Format Journal Article
LanguageChinese
Published China 01.09.2008
Subjects
Alkaloids - chemistry
Alkaloids - isolation & purification
Amides - chemistry
Amides - isolation & purification
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Ergosterol - analogs & derivatives
Ergosterol - chemistry
Ergosterol - isolation & purification
Fungi - chemistry
Magnetic Resonance Spectroscopy
Marine Biology
Molecular Structure
Mycelium - chemistry
Phytosterols - chemistry
Phytosterols - isolation & purification
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Summary:To study the chemical constituents of a marine-derived fungus possessing anti-tumor activity. The compounds were isolated by various chromatographic methods and their structures were elucidated through spectroscopic analysis and chemical and physical properties. Nine compounds were isolated and identified as: (S)-(-)-N-benzoylphenylalaninol, asperphnamate, cerevisterol, (22E, 24R)-6beta-methnoxyergosta-7,22-diene-3beta, 5alpha-diol, (22E, 24R)-5alpha, 6alpha-epoxy-ergosta-8, 22-diene-3beta, 7alpha-diol, (22E, 24R) -3beta, 5alpha, 9alpha-trihydroxyergosta-7, 22-diene-6-one, (22E, 24R) -3beta-hydroxy-ergosta-5, 8, 22-trien-7-one, ergosterol, ergosterol peroxide. (22E, 24R)-3beta-hydroxy-ergosta-5, 8, 22-trien-7-one is isolated from microorganisms for the first time.
ISSN:1001-4454