Levels of Toll-like receptors-2,-4 on platelets in children with idiopathic thrombocytopenic purpura

To study the changes and significance of Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) on platelets, CD86 on lymphocytes and concentrations of IL-2, IFN-gamma, IL-4 and IL-10 in serum in children with idiopathic thrombocytopenic purpura (ITP). Peripheral blood samples were collected fr...

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Published inZhongguo dang dai er ke za zhi Vol. 11; no. 10; p. 797
Main Authors Wang, Chun-Mei, Sheng, Guang-Yao, Zou, Xiang, Bai, Song-Ting, Wang, Lu
Format Journal Article
LanguageChinese
Published China 01.10.2009
Subjects
Adolescent
B7-2 Antigen - blood
Blood Platelets - chemistry
Child
Child, Preschool
Cytokines - blood
Humans
Infant
Purpura, Thrombocytopenic, Idiopathic - immunology
Toll-Like Receptor 2 - blood
Toll-Like Receptor 4 - blood
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Summary:To study the changes and significance of Toll-like receptor-2 (TLR2) and Toll-like receptor-4 (TLR4) on platelets, CD86 on lymphocytes and concentrations of IL-2, IFN-gamma, IL-4 and IL-10 in serum in children with idiopathic thrombocytopenic purpura (ITP). Peripheral blood samples were collected from 24 children with acute idiopathic thrombocytopenic purpura (AITP), 21 children with chronic idiopathic thrombocytopenic purpura (CITP) and 20 normal children (control group). Expression of TLR2 and TLR4 on platelets and CD86 on lymphocytes were detected by flow cytometry. Serum concentrations of IL-2, IL-4, IL-10 and IFN-gamma were measured using ABC-ELISA. The expression of CD41+TLR2+ and CD61+TLR4+ in the AITP and the CITP groups were significantly lower than those in the control group (p<0.01). The AITP group had lower expression of CD41+TLR2+ and CD61+TLR4+ than the CITP group (p<0.01). The expression of CD86+ in the AITP and the CITP groups was significantly higher than that in the control group (p<0.01). T
ISSN:1008-8830