Changes of VEGF, TNF-alpha, IL-6 and NO in serum of patients with HAPE

• Published in: Zhongguo ying yong sheng li xue za zhi Vol. 27; no. 2; p. 201
• Main Authors: Ran, Yu-Hua, Zhang, Dong-Xiang, Xiao, Zhong-Hai, Zhang, Yan-Fang, Cui, Wen-Yu, Wang, Yin-Hu, Cui, Jian-Hua, Wang, Hai
• Format: Journal Article
• Language: Chinese
• Published: China 01.05.2011
• Subjects: Adult; Altitude; Altitude Sickness - complications; Altitude Sickness - physiopathology; Humans; Interleukin-6 - blood; Male; Nitric Oxide - blood; Pulmonary Edema - blood; Pulmonary Edema - etiology; Pulmonary Edema - physiopathology; Tumor Necrosis Factor-alpha - blood; Vascular Endothelial Growth Factor A - blood
• ISSN: 1000-6834

To explore the possible pathophysiological process and mechanisms underlying the development and formation of high altitude pulmonary edema(HAPE) by observing the changes in contents of VEGF, TNF-alpha, IL-6 and NO in serum from the initiated and recovery of HAPE patients. We studied 10 HAPE patients in a Chinese population. The patients were divided into two groups including HAPE initiate group and the recovery group. Contents of VEGF, TNF-alpha, IL-6 and NO in serum of the two groups were determined to study the process of HAPE. VEGF levels in the HAPE initiate one and the recovery groups were (167.9 +/- 26.5 and 53.1 +/- 17.0 pg/ ml), respectively. There was a significant decrease of VEGF content in recovery one compared to the HAPE group. The same results for TNF-alpha were gained. The levels of TNF-alpha in recovery group was much lower than that in the HAPE initiate one. They were (29.2 +/- 6.8) pg/ml and (86.2 +/- 24.1) pg/ml, respectively. The contents of IL-6 in HAPE initiate group and the recovery g