Visualization of iron nanoparticles accumulation and distribution features in sensitive and resistant to antitumor drugs human breast cancer cells after different time intervals of cultivation with liposomal ferromagnetic

• Published in: TSitologiia i genetika Vol. 45; no. 6; p. 61
• Main Authors: Nalieskina, L A, Luk'ianova, N Iu, Kuns'ka, L M, Demash, D V, Chekhun, V F
• Format: Journal Article
• Language: Ukrainian
• Published: Ukraine 01.11.2011
• Subjects: Antineoplastic Agents - pharmacology; Breast Neoplasms - drug therapy; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Cell Membrane - drug effects; Cell Membrane - metabolism; Cell Proliferation - drug effects; Cell Survival - drug effects; Cisplatin - pharmacology; Cytoplasm - drug effects; Cytoplasm - metabolism; Doxorubicin - pharmacology; Drug Resistance, Neoplasm - drug effects; Endocytosis - drug effects; Female; Fiber Optic Technology; Histocytochemistry; Humans; Iron - metabolism; Iron - pharmacology; Kinetics; Liposomes - chemistry; Liposomes - metabolism; Liposomes - pharmacology; Magnetite Nanoparticles - administration & dosage; Magnetite Nanoparticles - therapeutic use; Molecular Targeted Therapy - methods; Time Factors
• ISSN: 0564-3783

It was shown in vitro that visualization of iron nanoparticles by histochemical Lilly method, modified by authors for cytomorphological studies, could be a certain control of ferromagnetic income to human breast cancer MCF-7 cells with different sensitivity to antitumor drugs (doxorubicin and cisplatin). The form of the visualized iron nanoparticles, their localization and distribution towards intracellular structures was studied. It was shown that localization, dynamics of accumulation and release of ferromagnetic from cells were connected to their sensitivity to antitumor drugs and time of incubation with iron nanoparticles.