Mannatide enhances the efficacy of fractionated and unfractionated radiotherapy in mice bearing Lewis lung cancer

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 31; no. 12; p. 2072
• Main Authors: Fan, Rui-tai, Hu, Yong, Liu, Jun-qi, Zhang, Jing-jing, Song, Rui, Gu, Hao
• Format: Journal Article
• Language: Chinese
• Published: China 01.12.2011
• Subjects: Animals; Biological Products - therapeutic use; Carcinoma, Lewis Lung - drug therapy; Carcinoma, Lewis Lung - radiotherapy; Combined Modality Therapy; Dose Fractionation; Dose-Response Relationship, Radiation; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Radiation-Sensitizing Agents - therapeutic use; Streptococcus
• ISSN: 1673-4254

To investigate the effect of mannatide injection (MI) in enhancing the efficacy of radiotherapy in two therapeutic schedules in mice bearing Lewis lung cancer. C57BL/6 mice bearing Lewis lung cancer xenograft were assigned randomly into control group, fractionated schedule (FS) group, nonfractionated schedule (NFS) group, MI group, FS+MI group, and NFS+MI group (n=10). MI (4.5 mg/kg) or saline was given intraperitoneally for 14 consecutive days in the corresponding groups. Radiation with 8 MeV electron beam was delivered in a single 4 Gy dose in NFS and in 4 fractions (total dose 4 Gy) in FS. Tumor inhibition rate and the spleen and thymus index were calculated after the treatments. MI significantly enhanced the efficacy of radiotherapy with a tumor inhibition rate reaching 70% in FS+MI group (P<0.01). FS resulted in a significantly higher tumor inhibition rate than NFS (P<0.05), but the rates were comparable between FS+MI and NFS+MI groups. The spleen index and thymus indices were significantly higher in FS+