Gene expression in patients with myelodysplastic syndrome

• Published in: Zhongguo shi yan xue ye xue za zhi Vol. 18; no. 3; p. 666
• Main Authors: Chen, Bao-An, Zhang, Bo, Gao, Chong, Gao, Feng, Xia, Guo-Hua, Shao, Ze-Ye, Ding, Jia-Hua, Zhao, Gang, Chen, Jian, Wang, Jun, Song, Hui-Hui, Bao, Wen, Zhong, Yue-Jiao, Pei, Xiao-Ping, Wang, Fei, Gu, Zhong-Ze
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2010
• Subjects: Aged; Bone Marrow Cells - metabolism; Case-Control Studies; CASP8 and FADD-Like Apoptosis Regulating Protein - genetics; CASP8 and FADD-Like Apoptosis Regulating Protein - metabolism; Female; Gene Expression; Humans; Intercellular Signaling Peptides and Proteins - genetics; Intercellular Signaling Peptides and Proteins - metabolism; Male; Membrane Proteins - genetics; Membrane Proteins - metabolism; Myelodysplastic Syndromes - genetics; RNA, Messenger - genetics
• ISSN: 1009-2137

This study was aimed to investigate the expression of c-FLIPL, c-FLIPS and DLK1 mRNA in the patients with myelodysplastic syndrome (MDS) and its clinical significance. The mRNA expression of c-FLIPL, c-FLIPS and DLK1 in bone marrow mononuclear cells (BMMNC) of 16 patients with MDS and 3 controls were detected by RT-PCR. The results indicated that the expression of DLK1 mRNA was up-regulated in MDS, including RA and RAEB, as compared with controls (p < 0.05). There was no significant difference in expression of DLK1 between RA and RAEB patients (p > 0.05); the expression of c-FLIPL mRNA both in RA and RAEB patients was higher than that in controls (p < 0.05). There was no significant difference in expression of c-FLIPL between RA and RAEB patients (p > 0.05); the expression of c-FLIPS mRNA was not significantly different between MDS patients and controls (p > 0.05), but its expression in RAEB patients was significantly higher as compared with RA patients and controls (p < 0.05). It is concluded that the mRNA e