A case of colonic neuroendocrine carcinoma with severe liver dysfunction by multiple liver metastases successfully treated with hepatic arterial infusion

• Published in: Gan to kagaku ryoho Vol. 38; no. 12; p. 2268
• Main Authors: Kikuchi, Akifumi, Yamauchi, Shinichi, Ono, Hiroaki, Kato, Syunsuke, Ishiguro, Megumi, Ishikawa, Toshiaki, Kobayashi, Hirotoshi, Iida, Satoru, Uetake, Hiroyuki, Higuchi, Tetsuro, Enomoto, Masayuki, Sugihara, Kenichi
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.11.2011
• Subjects: Antimetabolites, Antineoplastic - administration & dosage; Antimetabolites, Antineoplastic - therapeutic use; Carcinoma, Neuroendocrine - drug therapy; Carcinoma, Neuroendocrine - pathology; Carcinoma, Neuroendocrine - surgery; Colonic Neoplasms - drug therapy; Colonic Neoplasms - pathology; Colonic Neoplasms - surgery; Combined Modality Therapy; Fatal Outcome; Fluorouracil - administration & dosage; Fluorouracil - therapeutic use; Humans; Infusions, Intra-Arterial; Liver Neoplasms - drug therapy; Liver Neoplasms - physiopathology; Liver Neoplasms - secondary; Male; Middle Aged; Tomography, X-Ray Computed
• ISSN: 0385-0684

A 63-year-old male was diagnosed as ascending colon cancer with severe liver dysfunction caused by multiple liver metastases. Initially, hepatic arterial infusion (HAI) chemotherapy was started to reduce the size of metastatic tumors and to prevent a liver failure. After 7 courses of HAI chemotherapy, he recovered from liver dysfunction, and underwent right hemicolectomy. Pathological examination of the resected specimen revealed the tumor was neuroendocrine carcinoma. After surgery, a systemic infusion of mFOLFOX6/bevacizumab regimen was started. A partial response (PR) of metastatic lesions was observed. Irinotecan/cetuximab was administered as the second-line. He survived for 10 months after HAI. HAI for colonic neuroendocrine carcinoma with severe liver dysfunction by multiple liver metastases might be benefitial to prevent a liver failure.