Analysis of expression of cancer stem cell-related markers in orbital adenoid cystic carcinoma

• Published in: Chung-hua yen k'o tsa chih Vol. 47; no. 8; p. 703
• Main Authors: Lin, Ting-ting, Zhu, Li-min, He, Yan-jin, Zhang, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2011
• Subjects: AC133 Antigen; Adolescent; Adult; Animals; Antigens, CD - metabolism; ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters - metabolism; Biomarkers, Tumor - metabolism; Carcinoma, Adenoid Cystic - metabolism; Carcinoma, Adenoid Cystic - pathology; Female; Glycoproteins - metabolism; Humans; Hyaluronan Receptors - metabolism; Male; Mice; Mice, Nude; Middle Aged; Neoplasm Proteins - metabolism; Neoplastic Stem Cells - metabolism; Orbital Neoplasms - metabolism; Orbital Neoplasms - pathology; Peptides - metabolism; Prognosis; Young Adult
• ISSN: 0412-4081
• DOI: 10.3760/cma.j.issn.0412-4081.2011.08.008

To observe the expression and distribution of CD44, CD133, and ABCG2 in orbital adenoid cystic carcinoma (ACC) and investigate their correlations with pathological type and prognosis. Two steps method of immunohistochemical staining was employed in 33 cases of paraffin embedded surgical specimens of human orbital ACC, 5 cases of recurrence samples, 3 cases of an excised lacrimal gland caused by neither inflammation nor tumor diseases, and 6 cases of xenograft tumors in nude mice. A retrospective analysis was performed on the clinical material of these patients, which were collected from Jan. 1991 to Mar. 2009. The positive rate of CD44 was 54.5% (18/33), with 76.9% (10/13) in solid type and 40.0% (8/20) in adeno-tubiform type. There was no statistically significant difference between them (P = 0.072). In solid type the positive expression cells were often located at the marginal part of the cancer nest. In the adeno-tubiform type, positive cells were often located at the outer layer of the tubiform structure