Clinicopathological features and prognosis of cystic gastrointestinal stromal tumor

• Published in: Zhonghua wei chang wai ke za zhi Vol. 14; no. 8; p. 599
• Main Authors: Wang, Cui-zhong, Hou, Ying-yong, Shen, Kun-tang, Wang, Hong-shan, Qin, Jing, Sun, Yi-hong, Qin, Xin-yu
• Format: Journal Article
• Language: Chinese
• Published: China 01.08.2011
• Subjects: Aged; Female; Gastrointestinal Stromal Tumors - diagnosis; Gastrointestinal Stromal Tumors - pathology; Humans; Male; Middle Aged; Prognosis; Retrospective Studies
• ISSN: 1671-0274

To investigate the clinicopathological and molecular genetic characteristics of gastrointestinal stromal tumor (GISTs) with significant cystic changes, and to assess their biological behavior. Clinicopathological features of 7 patients with cystic GISTs treated at the Zhongshan Hospital of Fudan University from February 2005 to January 2010 were summarized retrospectively. The mutations status of c-kit and PDGFR-α were analyzed. There were 2 males and 5 females aged from 46 to 76 years old. Primary site of GISTs included stomach(n=4), duodenum(n=1), and small intestinal(n=2). Tumor size ranged from 6 to 16 cm with obviously cystic changes. Tumor cells were found in the solid components under microscope, of which epithelioid cell type were found in 4 case and spindle cell type in 3 cases. The mitotic figures were no more than 3/50 HPF in all the patients. According to the NIH criteria, 4 were high-risk and 3 were low-risk. Based on morphological characteristics, 3 cases were as borderline tumor, 3 moderate-ris