Surgical treatment for clinical stage II and III small cell lung cancer patients

To evaluate a surgical resection in multidisciplinary treatment for clinical stage (c-stage) II and III small cell lung cancer (SCLC) patients, we examined the postoperative prognosis concerning in 18 patients who underwent complete surgical resection. Five-year survival rate of 8 c-stage II and 10...

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Bibliographic Details
Published inKyobu geka. The Japanese journal of thoracic surgery Vol. 59; no. 10; p. 879
Main Authors Kawano, Ryoji, Tamaki, K, Karita, S, Yokota, T, Ikeda, S, Hata, E
Format Journal Article
LanguageJapanese
Published Japan 01.09.2006
Subjects
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Carcinoma, Small Cell - drug therapy
Carcinoma, Small Cell - mortality
Carcinoma, Small Cell - pathology
Carcinoma, Small Cell - surgery
Combined Modality Therapy
Female
Humans
Lung Neoplasms - drug therapy
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Male
Middle Aged
Neoplasm Staging
Pneumonectomy - mortality
Survival Rate
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Summary:To evaluate a surgical resection in multidisciplinary treatment for clinical stage (c-stage) II and III small cell lung cancer (SCLC) patients, we examined the postoperative prognosis concerning in 18 patients who underwent complete surgical resection. Five-year survival rate of 8 c-stage II and 10 c-stage III patients showed 62.5% and 46.7%, respectively. Of these, 7 patients underwent preoperative induction chemotherapy resulting in down-staging to c-stage 0-I, and their survival rate at 5 years after sugery was as good as 68.6%. However, in 4 (57.1%) of 7 patients, tumor cells proved to be alive by pathological assessment of lymph nodes. As a consequence, it was suggested that surgery for c-stage II and III SCLC patients is a meaningful treatment considering their prognoses. In particular, even though the patients show a favorable response of preoperative chemotherapy, to completely eliminate remnant tumor cells, a surgical resection may be necessary.
ISSN:0021-5252