Markedly increased red cell fragmentations counted as platelets in a patient with thrombotic microangiopathy

A patient with acute lymphocytic leukemia (ALL) experienced severe thrombotic microangiopathy (TMA) after allo-bone marrow transplantation (BMT). She had high risk for TMA; due to total body irradiation (TBI), intensive chemotherapy, treatment with Ciclosporin and association with veno-occlusive dis...

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Bibliographic Details
Published inRinsho byori. The Japanese journal of clinical pathology Vol. 53; no. 4; p. 303
Main Authors Wada, Hideo, Sakakura, Miho, Fujieda, Atsusi, Sakaguchi, Akane, Abe, Yasunori
Format Journal Article
LanguageJapanese
Published Japan 01.04.2005
Subjects
Adult
Erythrocytes - pathology
Female
Humans
Platelet Count - standards
Purpura, Thrombotic Thrombocytopenic - blood
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Summary:A patient with acute lymphocytic leukemia (ALL) experienced severe thrombotic microangiopathy (TMA) after allo-bone marrow transplantation (BMT). She had high risk for TMA; due to total body irradiation (TBI), intensive chemotherapy, treatment with Ciclosporin and association with veno-occlusive disease (VOD). Markedly increased fragmentations of red blood cells were observed in this case, and were incorrectly counted as platelets by a fully automated blood cells counter. Careful evaluation of the platelet count is necessary in patients with red cell fragmentations.
ISSN:0047-1860