Design, synthesis and insulin-sensitizing activity of indole derivatives

To design and synthesize compounds with insulin-sensitizing activity. Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-a...

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Bibliographic Details
Published inYao hsüeh hsüeh pao Vol. 41; no. 3; p. 225
Main Authors Tang, Lei, Yang, Yu-she, Ji, Ru-yun
Format Journal Article
LanguageChinese
Published China 01.03.2006
Subjects
3T3-L1 Cells - metabolism
Adipocytes - drug effects
Animals
Drug Design
Hypoglycemic Agents - chemical synthesis
Hypoglycemic Agents - pharmacology
Indoles - chemical synthesis
Indoles - pharmacology
Insulin - pharmacology
Mice
Triglycerides - metabolism
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Summary:To design and synthesize compounds with insulin-sensitizing activity. Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells. One of the synthesized compounds showed strong insulin-sensitizing activity in vitro. This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.
ISSN:0513-4870