Effect of qianggu drink ([Chinese characters: see text) on bone histomorphometry of lumbar vertebrae in ovariectomized rats

• Published in: Zhongguo gu shang Vol. 21; no. 4; p. 287
• Main Authors: Shi, Xiao-lin, Wu, Lian-guo, Xu, Jian-chun
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2008
• Subjects: Animals; Female; Humans; Lumbar Vertebrae - drug effects; Lumbar Vertebrae - pathology; Osteoporosis, Postmenopausal - drug therapy; Ovariectomy; Rats; Rats, Sprague-Dawley
• ISSN: 1003-0034

To observe the effect of Chinese herbal medicine Qianggu drink ([Chinese characters: see text]) on bone histomorphometry of lumbar vertebrae in ovariectomized rats and to explore its mechanism. Sixty female SD rats (weight 230 to 280 gram) were randomized into three groups: Qianggu drink ([Chinese characters: see text]) group (treatment group), Miacalcic group (control group) and blank group. The osteoporosis model was established successfully after all rats were ovariectomized for 10 weeks. The treatment group was used intragastric infusion with Qianggu drink ([Chinese characters: see text]) 0.001 ml/kg once a day. The control group was used hypodermic injection once a day with Miacalcic 0.72 U/kg. Five rats were killed respectively and the lumbar specimens were taken and cut for bone histomorphometric analysis at 45, 90, 135 and 180 days after the treatment. The thickness of trabecular bone in treatment group had the statistical significance with control group at 135 days after ovariectomized rats were give