Fisher syndrome with optic neuropathy

Fisher syndrome with optic neuropathy has been rarely reported. We report a 78-year-old Frenchman with Fisher syndrome. The patient complained of dizziness and bilateral blurred vision. His corrected visual acuity was 0.03 in the right eye, and 0.02 in the left eye. Deep tendon reflexes were absent....

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Bibliographic Details
Published inNippon Ganka Gakkai zasshi Vol. 112; no. 9; p. 801
Main Authors Koga, Noriko, Ishikawa, Hiroshi, Itou, Yuu, Minami, Masayuki, Mizutani, Tomohiko
Format Journal Article
LanguageJapanese
Published Japan 01.09.2008
Subjects
Aged
Biomarkers - blood
Gangliosides - immunology
Humans
Immunoglobulin G - blood
Immunoglobulins, Intravenous - therapeutic use
Male
Miller Fisher Syndrome - complications
Miller Fisher Syndrome - diagnosis
Miller Fisher Syndrome - drug therapy
Optic Nerve Diseases - complications
Optic Nerve Diseases - diagnosis
Optic Nerve Diseases - drug therapy
Treatment Outcome
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Summary:Fisher syndrome with optic neuropathy has been rarely reported. We report a 78-year-old Frenchman with Fisher syndrome. The patient complained of dizziness and bilateral blurred vision. His corrected visual acuity was 0.03 in the right eye, and 0.02 in the left eye. Deep tendon reflexes were absent. A few days later, bilateral complete external ophthalmoplegia appeared. Both pupils were dilated and pupillary reflexes were absent. Serum anti-GQlb antibodies and anti-GT1a antibodies were detected. After intravenous immunoglobulin treatments, all neurological symptoms including optic neuropathy and external ophthalmoplegia disappered except for pupillary dilatation associated with light-near dissociation. Tonic pupil indicated disorder of the peripheral nervous system. Fisher syndrome may complicate optic neuropathy.
ISSN:0029-0203