Tubular differentiation in African breast cancer

In an effort to determine numerical thresholds for histological breast cancer grading, we evaluated the fraction of fields with tubular differentiation (FTD) in Nigerian breast cancers (n=300). Analyses were based on Kaplan-Meier survival curves, and univariate and multivariate analyses by Cox'...

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Bibliographic Details
Published inAdvances in clinical pathology : the official journal of Adriatic Society of Pathology Vol. 7; no. 1; p. 27
Main Authors Ikpatt, O F, Kuopio, T, Collan, Y, Ndoma-Egba, R
Format Journal Article
LanguageEnglish
Published Italy 01.01.2003
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - therapy
Carcinoma, Ductal, Breast - mortality
Carcinoma, Ductal, Breast - secondary
Carcinoma, Ductal, Breast - therapy
Combined Modality Therapy
Epithelial Cells - pathology
Female
Humans
Lymph Nodes - pathology
Lymphatic Metastasis
Mammary Glands, Human - pathology
Middle Aged
Nigeria - epidemiology
Prognosis
Survival Rate
Young Adult
Nigeria
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Summary:In an effort to determine numerical thresholds for histological breast cancer grading, we evaluated the fraction of fields with tubular differentiation (FTD) in Nigerian breast cancers (n=300). Analyses were based on Kaplan-Meier survival curves, and univariate and multivariate analyses by Cox's regression. The mean (SD) value of FTD in Nigeria, 16.7 (19.3)%, was much lower than reported in European breast cancer. Decreasing FTD was associated with increasing histological grades (p < 0.0001) and clinical stage (p = 0.0190). The most significant cut-point for FTD in predicting outcome was 15.0%. In univariate analysis, FTD 15% was a significant prognosticator in the whole material, in larger than 5cm tumours, among postmenopausal and premenopausal patients, and LN+ patients. After multivariate analysis with mitotic count, FTD was an independent prognosticator among tumours larger than 5cm, but not in other groups. We conclude that the rational grading of breast cancers need be optimised according to diagnostic and therapeutic environment. We propose FTD 15% as a cut-point to grade breast cancer in Nigerian material.
ISSN:1125-5552