Effect of mexidol on the magnitude of a systemic inflammatory response in patients at aortocoronary bypass surgery

• Published in: Anesteziologiia i reanimatologiia no. 4; p. 27
• Main Authors: Eremenko, A A, Ziuliaeva, T P, Egorov, V M, Sidorenko, Ia V, Fominykh, M V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.07.2008
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antioxidants - administration & dosage; Antioxidants - pharmacology; Antioxidants - therapeutic use; Coronary Artery Bypass; Coronary Disease - surgery; Cytokines - immunology; Female; Humans; Male; Middle Aged; Picolines - administration & dosage; Picolines - pharmacology; Picolines - therapeutic use; Postoperative Complications - etiology; Postoperative Complications - immunology; Postoperative Complications - metabolism; Postoperative Complications - prevention & control; Reactive Oxygen Species - metabolism; Systemic Inflammatory Response Syndrome - etiology; Systemic Inflammatory Response Syndrome - immunology; Systemic Inflammatory Response Syndrome - metabolism; Systemic Inflammatory Response Syndrome - prevention & control; Time Factors
• ISSN: 0201-7563

to evaluate the efficiency of pharmacological correction of a systemic inflammatory response in patients after coronary bypass surgery, by using mexidol. 40 patients with coronary heart disease, who had undergone myocardial revascularization were examined. A study group (n = 20) received mexidol within 5 days before, during, and 5 days after surgery. A control group (n = 20) were given 0.9% NaCl solution. The degree of a systemic inflammatory response was estimated from the levels of C-reactive protein (CRP), the cytokines IL-6, IL-8, and TNF-alpha. The activities of serum enzymes and myoglobin were determined. after surgery, both groups showed the elevated concentrations of IL-6, IL-8, TNF-alpha, and CRP, but their elevation was statistically significant less in the study group than in the control one (p < 0.05). In both groups, there were increases in the levels of alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transpeptidase, lactate dehydrogenase, creatinine phosphokinase, and myoglobin, which was statistically significant more apparent in the control group (p < 0.05). mexidol diminishes the magnitude of a systemic response after aortocoronary bypass surgery under extracorporeal circulation and has an organ-protective effect.