Alternative changes of activity of alpha2-macroglobulin and alpha1-antitrypsin in rat blood following damage in capsaicin-sensitive nerves

• Published in: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 92; no. 9; p. 1078
• Main Authors: Tolochko, Z S, Spiridonov, V K
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.09.2006
• Subjects: alpha 1-Antitrypsin - blood; alpha 1-Antitrypsin - metabolism; alpha-Macroglobulins - metabolism; Animals; Capsaicin - toxicity; Male; Neurons, Afferent - drug effects; Peripheral Nerves - drug effects; Rats; Rats, Wistar
• ISSN: 0869-8139

Effects of functional ablation of peptidergic sensory nerves with neurotoxic doses of capsaicin (150 mg/kg, s/c) as well as of their stimulation with small doses of capsaicin (5 mg/kg, i/p) on activity of proteinase inhibitors: alpha1-antitrypsin (alpha1-AT)-serine proteinase inhibitor and alpha2-macroglobulin (alpha2-MG)-nonspecific inhibitor were investigated in rat blood. The present results indicate alternative changes in activity of these proteinase inhibitors after damage of capsaicin-sensitive nerves: increasing decline in activity of alpha1-AT 1 and 3 or 14 days after administration of capsaicin and increase in activity of alpha2-MG land 3 day after the injection. The stimulation of afferent nerves with capsaicin did not change activity of the proteinase inhibitors 1 and 24 hours after the injection. It is suggested that the stable decrease in activity of alpha1-AT during a long period after the damage of capsaicin-sensitive nerves indicates an important role for these nerves in the regulating alpha1-AT that may exert a tonic effect on the activity alpha1-AT.