Protective effect of Danzhi-xiaoyao San on rat brain energy or material metabolism (correction of matebolism) dealt with D-galactose

• Published in: Hang tian yi xue yu yi xue gong cheng Vol. 18; no. 1; p. 32
• Main Authors: Cai, Da-yong, Chen, Jin-xing, Zhang, Wei, Wang, Xue, Sun, Li-ping, Zhang, Jia-jun, Huang, Qi-fu
• Format: Journal Article
• Language: Chinese
• Published: China 01.02.2005
• Subjects: Aldehyde Reductase - metabolism; Alzheimer Disease; Animals; Brain - drug effects; Brain - metabolism; Cholinesterase Inhibitors - pharmacology; Disease Models, Animal; DNA - metabolism; Drugs, Chinese Herbal - pharmacology; Galactose; Indans - pharmacology; Nootropic Agents - pharmacology; Piperidines - pharmacology; Proteins - metabolism; Rats; Rats, Wistar; RNA, Messenger - metabolism
• ISSN: 1002-0837

To research the mechanism of Danzhi-xiaoyao San (DZXYS) for treating Alzheimer's disease model of rats dealt with D-galactose. An Alzheimer's disease-like model of rats has been set up with sc. D-galactose 150.0 mg kg-1 D-1 x 49 d. Comparing with Acricept in 0.54 mg kg-1 D-1 dosage as a positive control drug, DZXYS in 12.636 g kg-1 D-1 x 49 d dosage has orally been administrated orally to treat the injury in the Alzheimer's disease-like model of rats. The energy charge in the cerebral tissues had been detested with waters liquid chromatography; the protein content and DNA content in the cerebral tissues had been detested with ultraviolet assay, the relative content of aldose reductase-mRNA is detested with RT-PCR. The difference was analyzed between the control rats without D-galactose, the model rats dealt with D-galactose, the model rats treated with Aricept and the model rats treated with DZXYS, it is significant as P<0.05. 1) DZXYS can not affect the energy charge in their cerebral tissues. 2) DZXYS can i