Influence of mandibular fracture upon intensity and prevailing direction of carbonate and citrate transport between blood and bones

• Published in: Stomatologija (Moskva) Vol. 85; no. 2; p. 14
• Main Authors: Petrovich, Iu A, Podorozhnaia, R P, Kichenko, S M, Dmitriev, I M
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 2006
• Subjects: Animals; Biological Transport; Carbon Radioisotopes - pharmacokinetics; Carbonates - metabolism; Citrates - metabolism; Disease Models, Animal; Follow-Up Studies; Fracture Healing - physiology; Mandible - diagnostic imaging; Mandible - metabolism; Mandible - pathology; Mandibular Fractures - diagnostic imaging; Mandibular Fractures - metabolism; Mandibular Fractures - pathology; Radionuclide Imaging; Rats
• ISSN: 0039-1735

Using new coefficient of the difference relative radioactivity (CD(RRA)) bone/blood there was studied [(14)C]-carbonate and [3-(14)C]-citrate in 1-month and 6-months rats after right-side fracture of the mandible in prevailing direction between blood and bone. Animals were taken out from the experiment 20 min after intraperitoneal injection of [(14)C]-carbonate and [3-(14)C]-citrate on 7th day after (stage of cell-fibrous callosity), on 14th day after (stage of chondroid callosity) and on 28th day after (stage of the primary bone callosity) the experiment start. Changes after injections of marked citrate and carbonate were similar. Input % (ratio pulse/min in bone and blood serum) and RRA in 1 week increased sharply, decreased in 2 weeks and less changing in 4 weeks. After fracture CD(RRA) in traumatized mandible and non traumatized femur in rats were changing in the opposite directions that testifies to the different prevailing directions of marked substances transport between blood and bones.