Long-term effects of early hyperbaric oxygen therapy on neonatal rats with hypoxic-ischemic brain damage

The application and therapeutic effect of hyperbaric oxygen (HBO) in hypoxic-ischemic brain damage (HIBD) remains controversial. Previous studies have focused on the early pathological and biochemical outcomes and there is a lack of long-term functional evaluation. This study was designed to evaluat...

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Published inZhongguo dang dai er ke za zhi Vol. 8; no. 3; p. 216
Main Authors Liu, Mei-Na, Zhuang, Si-Qi, Zhang, Hong-Yu, Qin, Zhao-Yuan, Li, Xiao-Yu
Format Journal Article
LanguageChinese
Published China 01.06.2006
Subjects
Acetylcholinesterase - analysis
Animals
Brain - pathology
Escape Reaction
Female
Hippocampus - enzymology
Hippocampus - pathology
Hyperbaric Oxygenation
Hypoxia-Ischemia, Brain - enzymology
Hypoxia-Ischemia, Brain - pathology
Hypoxia-Ischemia, Brain - therapy
Male
Maze Learning
Nitric Oxide Synthase - analysis
Rats
Rats, Sprague-Dawley
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Summary:The application and therapeutic effect of hyperbaric oxygen (HBO) in hypoxic-ischemic brain damage (HIBD) remains controversial. Previous studies have focused on the early pathological and biochemical outcomes and there is a lack of long-term functional evaluation. This study was designed to evaluate the long-term pathological and behavioral changes of early HBO therapy on neonatal rats with HIBD. Postnatal 7 days (PD7) rat pups were randomly assigned into Control (n=18), HIBD (n=17) and HBO treatment groups (n=17). HIBD was induced by ligating the left common carotid, followed by 2 hrs hypoxia exposure in the HIBD and HBO treatment groups. The Control group was sham-operated and was not subjected to hypoxia exposure. The HBO therapy with 2 atmosphere absolutes began 0.5-1 hr after HIBD in the HIBD treatment group, once daily for 2 days. The spatial learning and memory ability were evaluated by the Morris water maze test at PD37 to PD41. The morphological and histological changes of the brain, including brain
ISSN:1008-8830