Characteristics of p53 protein stabilization in cells of patients with ataxia-telangiectasia after gamma-irradiation

Stabilization of P53 protein in cells isolated from patients with a grave hereditary disease ataxia-telangiectasia (AT), characterized by strongly enhanced sensitivity to ionizing radiation and impairment of cell cycle control after DNA damage, was studied. The level of expression of these reactions...

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Bibliographic Details
Published inT͡S︡itologii͡a Vol. 47; no. 10; p. 898
Main Authors Spivak, I M, Smirnova, N V, Pleskach, N M, Ledashcheva, T A, Mikhel'son, V M
Format Journal Article
LanguageRussian
Published Russia (Federation) 2005
Subjects
Ataxia Telangiectasia - metabolism
Ataxia Telangiectasia - pathology
Cell Line
Child
Child, Preschool
Female
Fibroblasts - metabolism
Fibroblasts - radiation effects
Gamma Rays
Humans
Male
Microscopy, Confocal
Tumor Suppressor Protein p53 - metabolism
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Summary:Stabilization of P53 protein in cells isolated from patients with a grave hereditary disease ataxia-telangiectasia (AT), characterized by strongly enhanced sensitivity to ionizing radiation and impairment of cell cycle control after DNA damage, was studied. The level of expression of these reactions by patients may vary, and it tends to be linked with the severity of the disease. In all AT strains studied, both acquired by the authors and obtained from foreign colleagues, we observed the alteration of timing and character of stabilization of P53 protein, after the action of ionizing radiation in sublethal dosage, as compared to that in cells from healthy donor.
ISSN:0041-3771