Autologous bone marrow stem cell transplantation for treatment terminal liver diseases

• Published in: Nan fang yi ke da xue xue bao = Journal of Southern Medical University Vol. 28; no. 7; p. 1207
• Main Authors: Pan, Xing-nan, Shen, Jian-kun, Zhuang, Yue-peng, Chen, Xian-li, Li, Yi-xin, Chen, Li-juan, Yang, Hong
• Format: Journal Article
• Language: Chinese
• Published: China 01.07.2008
• Subjects: Adolescent; Adult; Aged; Bone Marrow Transplantation - methods; Female; Humans; Liver Cirrhosis - physiopathology; Liver Cirrhosis - surgery; Liver Failure - physiopathology; Liver Failure - surgery; Liver Function Tests; Male; Middle Aged; Stem Cell Transplantation - methods; Transplantation, Autologous; Treatment Outcome; Young Adult
• ISSN: 1673-4254

To evaluate the effect of autologous bone marrow-derived stem cell (BMSCs) transplantation in the treatment of liver failure and decompensated hepatic cirrhosis. Bone marrow was harvested (65-95 ml) from 24 patients in the transplantation group. The BMSCs were isolated and infused into liver or spleen of patients via hepatic or splenic artery. At different time points after the transplantation, the patients' liver function and prothrombin time (PT) were evaluated, and the survival rate and symptoms of the patients were recorded. All the serum biochemical indexes remained stable 2 weeks after the transplantation, and at 4 weeks after transplantation, albumin level increased significantly in comparison with the preoperative level (P<0.05). At 12 weeks, the albumin level further increased (P<0.01) along with Pre-ALB (P<0.01), while total bilirubin, tolal bile acid, PT and fibrinogen were all significantly lowered (P<0.05), and globulin, ALT, and AST remained unchanged (P>0.05). One week after the transplantation