Relationship between oxidized lipoprotein, angiogenesis and human coronary atherosclerotic plaque stabilization

• Published in: Zhonghua bing li xue za zhi Vol. 35; no. 3; p. 138
• Main Authors: Wei, Li-xin, Tang, Qing-he, Sun, Lu, Shi, Huai-yin, Guo, Ai-tao, You, Lian-bi
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2006
• Subjects: Angina, Unstable - metabolism; Angina, Unstable - pathology; Coronary Artery Disease - metabolism; Coronary Artery Disease - pathology; Humans; Immunohistochemistry; Lipoproteins, LDL - metabolism; Myocardial Infarction - metabolism; Myocardial Infarction - pathology; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology
• ISSN: 0529-5807

To analyze the relationship between oxidized low density lipoprotein (oxLDL), angiogenesis and stabilization of atherosclerotic plaques in human coronary arteries; and to investigate the role of oxLDL in creating vulnerable sites in atherosclerotic plaques. Samples of coronary arteries were obtained at autopsies of 42 patients with acute coronary syndrome. Eighty randomly selected blocks were studied by immunohistochemistry using antibodies against oxLDL and endothelial cells (factor VIII). Computer-aided planimeter was used for quantitative analysis. In unstable plaques, percentage of immunoreactive areas for oxLDL was significantly higher than that in stable plaques. Most of the oxLDL were located in shoulder region of these plaques, as compared to the fibrous cap and basal regions. The details of distribution of oxLDL were as follows: shoulder region (20.43 +/- 3.12 for unstable plaques and 17.65 +/- 4.22 for stable plaques), fibrous cap (4.77 +/- 2.03 for unstable plaque and 2.80 +/- 0.22 for stable plaqu