Association between polymorphism of CYP17 gene and serum hormone concentrations in aged men

To investigate the association between polymorphism of CYP17 gene and serum hormone concentrations in aged men. Eighty-three healthy men at the average age of 66.7 were divided into a < 66.7 group (n = 36) and a > 66.7 group (n = 47), and the polymorphism of CYP17 gene in the 5' promoter...

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Published inZhonghua nan ke xue Vol. 11; no. 6; p. 442
Main Authors Wang, Jun-Qi, Gu, Xiang, Chen, Jia-Cun, Sun, Xiao-Qing, Mu, Hong-Tao, Wei, Zeng-He, Li, Ming, Xin, Dian-Qi, Na, Yan-Qun
Format Journal Article
LanguageChinese
Published China 01.06.2005
Subjects
Adult
Aged
Aged, 80 and over
Estradiol - blood
Genotype
Humans
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Steroid 17-alpha-Hydroxylase - genetics
Testosterone - blood
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Summary:To investigate the association between polymorphism of CYP17 gene and serum hormone concentrations in aged men. Eighty-three healthy men at the average age of 66.7 were divided into a < 66.7 group (n = 36) and a > 66.7 group (n = 47), and the polymorphism of CYP17 gene in the 5' promoter region was investigated by PCR using DNA from the men's peripheral blood lymphocytes. A new recognition site was created for the restriction enzyme MspA1 I by transition (T --> C) in the risk allele (A2). Three genotypes A1/A1, A1/A2, A2/A2 were established, serum sex-hormone levels measured, and mean hormone concentration evaluated in each genotype and age group. No evidence was found that the testosterone (T) level, estrogen (E2) level and T/E2 ratio were associated with the genotype of CYP17 gene. There was no significant difference in T and E2 levels between the two groups, but there was a significant increase in the T/E2 ratio (P < 0.05). A2 allele does not increase sex hormone levels in aged men, but the T/E, ratio was
ISSN:1009-3591