Association between polymorphism of CYP17 gene and serum hormone concentrations in aged men
To investigate the association between polymorphism of CYP17 gene and serum hormone concentrations in aged men. Eighty-three healthy men at the average age of 66.7 were divided into a < 66.7 group (n = 36) and a > 66.7 group (n = 47), and the polymorphism of CYP17 gene in the 5' promoter...
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Published in | Zhonghua nan ke xue Vol. 11; no. 6; p. 442 |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | Chinese |
Published |
China
01.06.2005
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Subjects | |
Online Access | Get more information |
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Summary: | To investigate the association between polymorphism of CYP17 gene and serum hormone concentrations in aged men.
Eighty-three healthy men at the average age of 66.7 were divided into a < 66.7 group (n = 36) and a > 66.7 group (n = 47), and the polymorphism of CYP17 gene in the 5' promoter region was investigated by PCR using DNA from the men's peripheral blood lymphocytes. A new recognition site was created for the restriction enzyme MspA1 I by transition (T --> C) in the risk allele (A2). Three genotypes A1/A1, A1/A2, A2/A2 were established, serum sex-hormone levels measured, and mean hormone concentration evaluated in each genotype and age group.
No evidence was found that the testosterone (T) level, estrogen (E2) level and T/E2 ratio were associated with the genotype of CYP17 gene. There was no significant difference in T and E2 levels between the two groups, but there was a significant increase in the T/E2 ratio (P < 0.05).
A2 allele does not increase sex hormone levels in aged men, but the T/E, ratio was |
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ISSN: | 1009-3591 |