Micro-albuminuria: a predictor of short-term mortality in acute ischaemic stroke

We studied 89 non-diabetic patients of acute ischaemic stroke, confirmed by imaging, admitted within 24 hours of onset, to investigate the prevalence and significance of micro-albuminuria (MA) as a predictor of in-hospital mortality. Two control groups consisted of 70 patients with non-stroke chroni...

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Published inJournal of the Indian Medical Association Vol. 106; no. 12; p. 783
Main Authors Ghosh, Soumitra, Bandyopadhyay, Sanjay Kumar, Bandyopadhyay, Ranjana, Ghosh, Souvik, Sarkar, Nirmalendu, Bandyopadhyay, Susanta Kumar
Format Journal Article
LanguageEnglish
Published India 01.12.2008
Subjects
Acute Disease
Adult
Aged
Aged, 80 and over
Albuminuria - epidemiology
Brain Ischemia - diagnosis
Brain Ischemia - epidemiology
Brain Ischemia - urine
Case-Control Studies
Comorbidity
Creatinine - urine
Female
Hospital Mortality
Humans
Male
Middle Aged
Predictive Value of Tests
Prevalence
Prognosis
Severity of Illness Index
Stroke - diagnosis
Stroke - mortality
Stroke - urine
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Summary:We studied 89 non-diabetic patients of acute ischaemic stroke, confirmed by imaging, admitted within 24 hours of onset, to investigate the prevalence and significance of micro-albuminuria (MA) as a predictor of in-hospital mortality. Two control groups consisted of 70 patients with non-stroke chronic neurological diseases and 60 age- and sex- matched healthy individuals. Spot urinary albumin-to-creatinine ratio was measured in first morning sample on days 1, 4 and/or 7. Functional status was assessed daily for 7 days by National Institute of Health Stroke Scale (NIHSS). Outcome data were recorded for 14 days. MA was found in 61.79% of acute ischaemic stroke patients on day 1 compared to 13% in non-stroke neurological patients and 7% of healthy controls. Patients with MA were older and had a higher systolic blood pressure. The 14-day disease-specific mortality was higher in patients with MA (25.45%) compared to patients without it (5.88%). High day 1 MA (>100 microg/mg) and rising or static value from day 1 to day 4 or day 7 correlated with statistically more chance of death. Increasing MA had a positive correlation with higher NIHSS score. Thus, MA was found to be a reliable predictor of shortterm in-hospital mortality in acute ischaemic stroke.
ISSN:0019-5847