Basic and clinical aspects of calcimimetics. Cinacalcet, effect and mechanisms of action

Calcimimetics drug such as cinacalcet suppress the secretion of parathyroid hormone by sensitizing parathyroid calcium receptors to extracellular ionized calcium. Standard treatment for secondary hyperparathyroidism is associated with the risk of hypercalcemia, but cinacalcet don't induce eleva...

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Bibliographic Details
Published inClinical calcium Vol. 18; no. 1; p. 20
Main Authors Nakanishi, Shohei, Fukagawa, Masafumi
Format Journal Article
LanguageJapanese
Published Japan 01.01.2008
Subjects
Cinacalcet Hydrochloride
Humans
Hyperparathyroidism, Secondary - drug therapy
Naphthalenes - pharmacokinetics
Naphthalenes - pharmacology
Naphthalenes - therapeutic use
Parathyroid Glands - drug effects
Receptors, Calcium-Sensing - antagonists & inhibitors
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Summary:Calcimimetics drug such as cinacalcet suppress the secretion of parathyroid hormone by sensitizing parathyroid calcium receptors to extracellular ionized calcium. Standard treatment for secondary hyperparathyroidism is associated with the risk of hypercalcemia, but cinacalcet don't induce elevation of serum calcium. And it is reported that cinacalcet attenuates parathyroid hyperplasia and it effects on other organs.
ISSN:0917-5857