Preoperation risk factor analysis in orthotopic liver transplantation with pre-transplant artificial liver support therapy

• Published in: Zhonghua gan zang bing za zhi Vol. 13; no. 3; p. 175
• Main Authors: Yuan, Jin-zhong, Ye, Qi-fa, Ming, Ying-zi, Hang, Zu-fa, Zhao, Ling-ling, Zhao, Xue-yi, Wang, Min-min, Zhang, Mao-zu, Wen, Zhi-xiang, Zhu, Shai-hong, Wu, Kun
• Format: Journal Article
• Language: Chinese
• Published: China 01.03.2005
• Subjects: Aged; Factor Analysis, Statistical; Female; Humans; Interleukin-10 - blood; Liver Cirrhosis - surgery; Liver Neoplasms - surgery; Liver Transplantation - methods; Liver, Artificial; Male; Middle Aged; Preoperative Care; Risk Factors; Treatment Outcome; Tumor Necrosis Factor-alpha - blood
• ISSN: 1007-3418

Orthotopic liver transplantation (OLT) is an accepted therapy for selected patients with advanced liver diseases. However, the early mortality rate after OLT remains relatively high due to the poor selection of candidates with various serious conditions. The aim of this study is to assess the value of pretransplantation artificial liver support treatment in reducing the pre-operation risk factors relating to early mortality after OLT. 50 adult patients in various stages of different etiologies who underwent OLT procedures had been treated with molecular adsorbent recycling system (MARS) preoperatively. The study was designed in two parts: the first one was to evaluate the effectiveness of a single MARS therapy by using some clinical and laboratory parameters which were supposed to be therapeutical pretransplantation risk factors. The second part was to study the patients undergoing OLT by using the regression analysis on preoperation risk factors relating to early (within 30 d after OLT) mortality rate. Among