Studies on dissolution rate in vitro of silymarin dropping pill

To test the dissolution rate of silymarin dropping pill as well as to be compared with other three commercial products of the silymarin. By UV spectrophotometry, we studied the dissolution conditions of silymarin dropping pill and compared its dissolution rate with Yiganling tablets (film-coating, s...

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Bibliographic Details
Published inZhongguo zhongyao zazhi Vol. 30; no. 4; p. 263
Main Authors Sun, Xia, Qiu, Ming-feng, Li, Shao-shun, Wang, Jian-xin, Shen, Qi, Jia, Wei
Format Journal Article
LanguageChinese
Published China 01.02.2005
Subjects
Capsules
Drugs, Chinese Herbal - administration & dosage
Drugs, Chinese Herbal - chemistry
Silymarin - administration & dosage
Silymarin - chemistry
Solubility
Spectrophotometry, Ultraviolet
Tablets
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Summary:To test the dissolution rate of silymarin dropping pill as well as to be compared with other three commercial products of the silymarin. By UV spectrophotometry, we studied the dissolution conditions of silymarin dropping pill and compared its dissolution rate with Yiganling tablets (film-coating, sugar-coating) and Legalon capsule which are available in the market. The dissolution parameters T50 and Td of silymarin dropping pill, Yiganling tablet (film-coating), Yiganling tablet (sugar-coating) and Legalon capsule are 6.78, 9.85 min, 51.01, 73.78 min, 74.35, 86.97 min and 53.10, 72.65 min. The dissolution rate of silymarin dropping pill is superior to that of two kinds of Yiganling tablets and Legalon capsule.
ISSN:1001-5302