Imipenem use in serious childhood infections

Imipenem plus cilastatin is a beta-lactam antibiotic with a broad spectrum and good tolerance. For this its use is indicated in serious infections even in children. The authors carried out a preliminary bacteriological study in patients affected by serious infection, cystic fibrosis, tumors, neutrop...

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Bibliographic Details
Published inJournal of chemotherapy (Florence) Vol. 3 Suppl 1; p. 218
Main Authors Pavesio, D, Pecco, P, Giacchino, M, Dotti, M
Format Journal Article
LanguageEnglish
Published England 01.01.1991
Subjects
Antineoplastic Agents - adverse effects
Antineoplastic Agents - therapeutic use
Bacterial Infections - drug therapy
Child
Cystic Fibrosis - complications
Humans
Imipenem - pharmacology
Neoplasms - complications
Neutropenia - complications
Retrospective Studies
Surgical Wound Infection - drug therapy
Thienamycins - pharmacology
Treatment Outcome
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Summary:Imipenem plus cilastatin is a beta-lactam antibiotic with a broad spectrum and good tolerance. For this its use is indicated in serious infections even in children. The authors carried out a preliminary bacteriological study in patients affected by serious infection, cystic fibrosis, tumors, neutropenia, subjects undergoing intensive therapy and those with abdominal surgical infection. Isolated microorganism sensitivity in these patients, towards imipenem was very high (89%-100%). With these premises, 35 patients with serious infections in various locations were treated only with imipenem. Of these, 15 were oncologic neutropenic and 20 normal. In the first group therapeutic success was 66.6% and in the second one 80%. Local and systemic tolerance always showed good results.
ISSN:1120-009X
1973-9478