Role of viscosity and permeability of erythrocyte plasmatic membrane in controlling the oxygen transport effectiveness by human hemoglobin on completion of space flight

Plasmatic membrane viscosity and permeability and hemoporphyrine conformation in human hemoglobin were studied on completion of long-duration space flight (LSF). Reversible increases in viscosity and selective permeability (Na+/H+ -turnover) of erythrocyte plasmatic membrane were observed immediatel...

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Published inAviakosmicheskaia i Äkologicheskaia meditsina Vol. 41; no. 2; p. 41
Main Authors Ivanova, S M, Maksimov, G V, Morukov, B V, Iarlykova, Iu V, Labetskaia, O I, Luneva, O G, Maksimova, N V, Brazhe, N A, Bryzgalova, N Iu, Parshina, E Iu
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2007
Subjects
Blood Viscosity - physiology
Cell Membrane Permeability - physiology
Erythrocyte Membrane - metabolism
Follow-Up Studies
Hemoglobins - metabolism
Humans
Hydrogen-Ion Concentration
Immunoenzyme Techniques
Intracellular Fluid - metabolism
Ion Transport
Oxygen - metabolism
Oxygen Consumption - physiology
Space Flight
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Summary:Plasmatic membrane viscosity and permeability and hemoporphyrine conformation in human hemoglobin were studied on completion of long-duration space flight (LSF). Reversible increases in viscosity and selective permeability (Na+/H+ -turnover) of erythrocyte plasmatic membrane were observed immediately after and in the period of recovery from LSF. Viscosity of lipids in both external and internal locations of plasmatic membrane in human erythrocytes was changed after LSF. The reversible rise of the Na+/H+ -turnover is likely to alter intracellular pH and oxygen binding with hemoglobin. The former is confirmed by the concurrent reversible decline in the deoxyhemoglobin ability to bind oxygen and the oxyhemoglobin ability to retain oxygen. In LSF and during readaptation to the normal gravity blood levels of hemoglobin and free iron are known to be reduced and may be answerable for the hypoxic state of human organism.
ISSN:0233-528X