Synaptonemal complex--an essential role in etiology of idiopathic azoospermia

Synaptonemal complex (SC) which is a meiosis-specific supramolecular proteinaceous structure plays a crucial role in condensation, pairing, recombination and disjunction of homologous chromosomes at meiosis I. In recent years,a series of new developments on SC has been made, including new findings i...

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Bibliographic Details
Published inYíchuán Vol. 28; no. 2; p. 231
Main Authors Zhang, Wei, Zhang, Si-Zhong, A, Zhou-Cun
Format Journal Article
LanguageChinese
Published China 01.02.2006
Subjects
Animals
Azoospermia - etiology
Azoospermia - genetics
Azoospermia - metabolism
Humans
Infertility, Male - genetics
Male
Meiosis - genetics
Synaptonemal Complex - genetics
Synaptonemal Complex - metabolism
Synaptonemal Complex - physiology
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Summary:Synaptonemal complex (SC) which is a meiosis-specific supramolecular proteinaceous structure plays a crucial role in condensation, pairing, recombination and disjunction of homologous chromosomes at meiosis I. In recent years,a series of new developments on SC has been made, including new findings in both component and function of SC. Abnormalities of SC resulting from genetic mutation can directly induce arrest of spermatogenesis in rat model. More importantly, in human male patients with non-obstructive infertility the fact that genetic variation of SC (e.g. SCP3) is the causative factor of idiopathic azoospermia had been confirmed, and the investigation of SCP1 is under way.
ISSN:0253-9772