The effect of prodigiozan on the postradiational recovery of hemopoiesis in long-term bone morrow cultures of mice of different genotypes

• Published in: Radiat͡s︡ionnai͡a︡ biologii͡a︡, radioėkologii͡a Vol. 45; no. 6; p. 715
• Main Authors: Lebedev, V G, Moroz, V V, Deshevoĭ, Iu B, Lirshchikov, A V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.2005
• Subjects: Adjuvants, Immunologic - pharmacology; Animals; Bone Marrow - radiation effects; DNA Repair - genetics; Genotype; Hematopoiesis - drug effects; Male; Mice; Mice, Mutant Strains; Prodigiozan - pharmacology; Radiation, Ionizing
• ISSN: 0869-8031

The influence of prodigiozan on the processes of postirradiation recovery of hemopoiesis in long-term bone morrow cultures of two strain mice, having genetic distinctions in the condition of systems of the reparation DNA was investigated. It was showh, that the irradiation of long-term bone morrow cultures of mice reparation-defective strain 101/H resulted in the greater degree damage of early haemopoietic precursors (GM-CFC), reduction of the amount of the immature and of the mature granulocytes and of the decrease of the number of stromall cells in the comparison with the bone morrow of reparation-capable mice (CBA x C57B1)F1. Under the introduction in cultures of prodigiozan for 24 hours prior to an radiation the distinctions of the speed of postirradiation recovery of hemopoiesis substantially smoothed out, and the protective effect of the drag in bone morrow cultures of mice 101/H was comparable to those, marked in bone morrow cultures of reparation-capable strain mice (CBA x C57B1)F1. It is supposed, that this effect can be caused by the activation of the hematopoietic microenvironment cellular elements and inclusion of the mechanisms of intercellular of interactions, which provide stimulation of the regenerative processes at action radioprotective drags and can in the certain degree to compensate the defect of the systems of the reparation DNA.