Observation of antibody screen of patients with autoimmune hemolytic anemia

To observe of alloantibodies of patients with autoimmune hemolytic anemia (AIHA), the alloantibodies masked by autoiantibody were detected by using chloroquine elution test, and the specificity of autoantibody was identified by ether elution test. The results showed that 19 cases out of 38 patients...

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Published inZhongguo shi yan xue ye xue za zhi Vol. 12; no. 6; p. 849
Main Authors Yang, Shao-Ming, Lan, Jiong-Cai, Hu, Li-Ya, Lou, Hong-Qing
Format Journal Article
LanguageChinese
Published China 01.12.2004
Subjects
ABO Blood-Group System
Adolescent
Adult
Anemia, Hemolytic, Autoimmune - immunology
Autoantibodies - blood
Blood Grouping and Crossmatching - methods
Erythrocytes - immunology
Female
Humans
Isoantibodies - blood
Male
Middle Aged
Rh-Hr Blood-Group System
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Summary:To observe of alloantibodies of patients with autoimmune hemolytic anemia (AIHA), the alloantibodies masked by autoiantibody were detected by using chloroquine elution test, and the specificity of autoantibody was identified by ether elution test. The results showed that 19 cases out of 38 patients with AIHA were positive detected by indirect antiglobulin test and in 7 cases of them alloantibodies in sera cases were found (1 case of anti-D, 4 cases of anti-E and 2 cases of anti-CE), in 5 cases of them alloantibody were detected carried blood group specificity (3 cases of anti-E, anti-C and anti-c 1 case respectively). In conclusion, detections of alloantibodies by chloroquine elution test and ether elution test were very important for transfusion safety in therapy of patients with AIHA.
ISSN:1009-2137