Aldosterone-to-renin ratio threshold for screening primary aldosteronism in Chinese hypertensive patients

In recent years, the assessment of the plasma aldosterone-to-renin ratio (ARR) has become a most effectively and commonly used method for screening primary aldosteronism from hypertensive patients. It is known that there is a large variance in ARR value between races and ARR is affected by many fact...

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Published inZhōnghuá xīnxuèguănbìng zázhì Vol. 34; no. 10; p. 868
Main Authors Chen, Shao-xing, Du, Yue-ling, Zhang, Jin, Gong, Yan-chun, Hu, Ya-rong, Chu, Shao-li, He, Qing-bo, Song, Yan-yan, Zhu, Ding-liang
Format Journal Article
LanguageChinese
Published China 01.10.2006
Subjects
Adult
Aged
Aldosterone - blood
China - epidemiology
Clinical Chemistry Tests - statistics & numerical data
Female
Humans
Hyperaldosteronism - diagnosis
Hyperaldosteronism - epidemiology
Hypertension - complications
Hypertension - epidemiology
Male
Mass Screening
Middle Aged
Potassium - blood
Reference Values
Renin - blood
Renin-Angiotensin System
China
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Summary:In recent years, the assessment of the plasma aldosterone-to-renin ratio (ARR) has become a most effectively and commonly used method for screening primary aldosteronism from hypertensive patients. It is known that there is a large variance in ARR value between races and ARR is affected by many factors, such as drugs, posture and serum potassium etc. The objective of this study is to establish the threshold of ARR for screening primary aldosteronism in Chinese hypertensive patients. A total of 110 hypertensive patients were recruited and divided into essential hypertension group (n=65) and adenoma/hyperplasia group (n=45) according to the adrenal contrast CT scan. Antihypertensive drugs which can affect ARR such as beta-blockers, dihydropyridine calcium channel blockers (CCBs), ACE inhibitors (ACEIs), angiotensin II receptor blockers (ARBs) and clonidine, were withdrawn for at least 2 weeks. Washout period for diuretics including spironolactone were 4 weeks. Non-dihydropyridine calcium channel blockers (slow
ISSN:0253-3758