Advanced gastric cancer responding to pathological CR after neoadjuvant TS-1 combined with CDDP therapy--report of a case

A 54-year-old woman with advanced gastric cancer was referred to our hospital. Because it was the yearend, we selected neoadjuvant TS-1 combined with CDDP therapy. TS-1 (60 mg bid) was administered orally for 21 consecutive days, and CDDP (60 mg/m(2)) was infused intravenously on day 8. One course w...

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Bibliographic Details
Published inGan to kagaku ryoho Vol. 33; no. 6; p. 807
Main Authors Tsuchiya, Yasunori, Nashimoto, Atsushi, Nakagawa, Satoru, Yabusaki, Hiroshi, Takii, Yasumasa, Tsuchiya, Yoshiaki, Tanaka, Otsuo, Ohta, Tamaki
Format Journal Article
LanguageJapanese
Published Japan 01.06.2006
Subjects
Adenocarcinoma - drug therapy
Adenocarcinoma - pathology
Adenocarcinoma - surgery
Administration, Oral
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cisplatin - administration & dosage
Drug Administration Schedule
Drug Combinations
Female
Gastrectomy
Humans
Infusions, Intravenous
Middle Aged
Neoadjuvant Therapy
Oxonic Acid - administration & dosage
Pyridines - administration & dosage
Remission Induction
Stomach Neoplasms - drug therapy
Stomach Neoplasms - pathology
Stomach Neoplasms - surgery
Tegafur - administration & dosage
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Summary:A 54-year-old woman with advanced gastric cancer was referred to our hospital. Because it was the yearend, we selected neoadjuvant TS-1 combined with CDDP therapy. TS-1 (60 mg bid) was administered orally for 21 consecutive days, and CDDP (60 mg/m(2)) was infused intravenously on day 8. One course was completed without serious toxicities. The primary tumor revealed partial response (PR) with no lymph node metastasis judged from barium meal study and upper GI endoscopic findings. After 3 weeks, a simple total gastrectomy with lymph node dissection was performed. The pathological diagnosis proved that there were no cancer cells in the primary lesion or regional lymph nodes, suggesting a complete response (CR) to chemotherapy. The postoperative course was uneventful, and she has been fine as an outpatient.
ISSN:0385-0684