Lysosomal stability in Oreochromis mossambicus (Peters) on exposure to surfactants

The three commonly used surfactants viz. anionic sodium dodecyl sulfate (SDS), cationic cetyl tri methyl ammonium bromide (CTAB) and non-ionic triton X-100 were toxic even at sub lethal levels (1 ppm for 30 days) to 0. mossambicus. Lysosomal stability index (LSI) was lowest in triton-exposed animals...

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Bibliographic Details
Published inIndian journal of experimental biology Vol. 43; no. 1; p. 96
Main Authors Bindu, P C, Philip, Babu, Chandran, R Vinu
Format Journal Article
LanguageEnglish
Published India 01.01.2005
Subjects
Acid Phosphatase - analysis
Acid Phosphatase - metabolism
Animals
Biomarkers - analysis
Cetrimonium Compounds - toxicity
Intracellular Membranes - drug effects
Intracellular Membranes - enzymology
Liver - drug effects
Liver - enzymology
Liver - ultrastructure
Lysosomes - drug effects
Lysosomes - enzymology
Octoxynol - toxicity
Sodium Dodecyl Sulfate - toxicity
Surface-Active Agents - toxicity
Tilapia - metabolism
Toxicity Tests
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Summary:The three commonly used surfactants viz. anionic sodium dodecyl sulfate (SDS), cationic cetyl tri methyl ammonium bromide (CTAB) and non-ionic triton X-100 were toxic even at sub lethal levels (1 ppm for 30 days) to 0. mossambicus. Lysosomal stability index (LSI) was lowest in triton-exposed animals in vitro. In vivo, CTAB was the most toxic. SDS, the anionic surfactant was the least toxic. The possible role of surfactant structure, critical micellar concentration (CMC) and metabolism in influencing the toxicity is discussed and mechanism of action via membrane lipid peroxidation is suggested.
ISSN:0019-5189