Study of correlation between Helicobacter pylori infection and hyperammonemia and hepatic encephalopathy in cirrhotic patients

To evaluate the relationship among helicobacter pylori (HP) infection, blood ammonia concentrations, and hepatic encephalopathy (HE) status, and to investigate the effect of HP eradication on blood ammonia levels and HE status in cirrhotic patients. Three hundred and sixty-eight cirrhotic patients w...

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Published inZhongguo wei zhong bing ji jiu yi xue Vol. 19; no. 7; p. 422
Main Authors Yang, Cun-she, Cao, Shuan-yu, He, Xiao-juan, Wang, Yong-xi, Zhang, Yong-li
Format Journal Article
LanguageChinese
Published China 01.07.2007
Subjects
Female
Helicobacter Infections - complications
Helicobacter pylori
Hepatic Encephalopathy - etiology
Humans
Hyperammonemia - etiology
Liver Cirrhosis - blood
Liver Cirrhosis - complications
Male
Middle Aged
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Summary:To evaluate the relationship among helicobacter pylori (HP) infection, blood ammonia concentrations, and hepatic encephalopathy (HE) status, and to investigate the effect of HP eradication on blood ammonia levels and HE status in cirrhotic patients. Three hundred and sixty-eight cirrhotic patients were enrolled. Patients were evaluated for the demographic profile, number connection test (NCT), HP infection, Child-Pugh degree of liver dysfunction, blood ammonia concentration and status of mentation. Patients with HP infection were given one week therapy with omeprazole plus clarithromycin and amoxicillin. (13)C urea breath test was performed, and the mental symptoms and blood ammonia levels were reassessed after the eradication therapy. (1) The overall HP infection rate was 70.1% (258/368 cases), and HE positive in 51.4%(189/368 cases). Subclinical hepatic encephalopathy (SHE) was diagnosed in 85 out of 19(47.5%) cirrhotics patients. (2) Blood ammonia concentrations in HP negative and HP positive cirrhotics we
ISSN:1003-0603